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Related Experiment Video

Updated: Jun 1, 2026

Single-port Non-liposuction Endoscopic Axillary Lymph Node Dissection in Breast Cancer Surgery

Single-port Non-liposuction Endoscopic Axillary Lymph Node Dissection in Breast Cancer Surgery

Published on: April 3, 2026

Locally advanced breast cancer.

P Willsher¹, N Kapucuoglu, I Ellis

¹CITY HOSP,DEPT HISTOPATHOL,NOTTINGHAM NG5 1PB,ENGLAND. CITY HOSP,DEPT CLIN ONCOL,NOTTINGHAM NG5 1PB,ENGLAND.

Oncology Reports

|May 20, 2011

Summary

This study found that p53 and BCL-2 proteins, and MIB 1 proliferation, do not predict radiotherapy response in breast cancer patients. However, MIB 1 levels decreased after treatment, indicating reduced proliferation.

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Area of Science:

Oncology
Radiotherapy Research
Molecular Biology

Background:

In vitro research suggests p53 and BCL-2 proteins influence apoptosis, and rapid cell proliferation impacts radiotherapy sensitivity.
The clinical significance of these biological factors in predicting patient response to radiotherapy requires further investigation.

Purpose of the Study:

To investigate the clinical relevance of p53 protein, BCL-2 protein, and MIB 1 antigen in predicting radiotherapy response in locally advanced breast cancer patients.

Main Methods:

Immunocytochemical staining was performed on primary tumors from 62 locally advanced breast cancer patients.
Assessed p53 protein, BCL-2 protein, and MIB 1 antigen expression.
Semi-quantitative assessment of MIB 1 staining before and after radiotherapy.

Main Results:

No significant correlation was found between p53 (p=1.0), BCL-2 (p=0.45), or MIB 1 (p=0.92) expression and radiotherapy response.
A significant reduction in MIB 1 positive cells was observed post-radiotherapy (p=0.04).

Conclusions:

p53, BCL-2, and MIB 1 expression are not clinically valuable predictors of radiotherapy response in locally advanced breast cancer.
The observed decrease in MIB 1 staining post-radiotherapy suggests reduced tumor cell proliferation correlates with treatment response.