Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 1, 2026

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
09:45

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers

Published on: October 28, 2015

Radiation enhancing effect of pentoxifylline.

M Tashiro1, K Hirokawa, T Tada

  • 1OSAKA PREFECTURAL HABIKINO HOSP,HABIKINO,OSAKA 583,JAPAN. YODOGAWA CHRISTIANS HOSP,OSAKA 533,JAPAN.

Oncology Reports
|May 20, 2011
PubMed
Summary

Pentoxifylline (PENTO) demonstrates a stronger radiosensitizing effect than SR 2508 (SR) in mice tumors. PENTO, combined with nicotinamide (NA), shows enhanced radiation effects with low toxicity, suggesting its clinical potential.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunology of Aging: the Birth of Inflammaging.

Clinical reviews in allergy & immunology·2021
Same author

Immunosenescence is both functional/adaptive and dysfunctional/maladaptive.

Seminars in immunopathology·2020
Same author

Anti-Ki antibodies recognize an epitope homologous with SV40 nuclear localization signal: clinical significance and reactivities in various immunoassays.

Modern rheumatology·2014
Same author

Cyclosporin A therapy for interstitial pneumonitis associated with rheumatic disease.

Modern rheumatology·2014
Same author

Induction of immunological tolerance by oral, but not intravenous and intraportal, administration of ovalbumin and the difference between young and old mice.

The journal of nutrition, health & aging·2006
Same author

Unexpected clinicopathological phenotype linked to small elongation of CAG repeat in SCA1 gene.

Journal of neurology·2005

Area of Science:

  • Oncology
  • Radiotherapy
  • Pharmacology

Background:

  • Developing effective radiosensitizers with minimal toxicity is crucial for cancer treatment.
  • Nitroimidazole derivatives like SR 2508 are effective radiosensitizers but exhibit significant neurotoxicity.
  • Pentoxifylline (PENTO) is a low-toxicity drug used for vascular disorders, with potential radiosensitizing properties.

Purpose of the Study:

  • To compare the radiation-enhancing effects and toxicity of pentoxifylline (PENTO) with the nitroimidazole derivative SR 2508 (SR).
  • To evaluate the combined effects of PENTO and SR with nicotinamide (NA) on radiosensitization.
  • To identify a safer alternative radiosensitizer for clinical application.

Main Methods:

  • Experimental tumor model in mice.

Related Experiment Videos

Last Updated: Jun 1, 2026

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
09:45

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers

Published on: October 28, 2015

  • Growth delay method to calculate enhancement ratio (ER).
  • Comparison of ER for PENTO and SR, alone and in combination with nicotinamide (NA).

    • Main Results:

    • PENTO exhibited a stronger radiosensitizing effect (ER=1.6) compared to SR (ER=1.4).
    • Combining PENTO with NA enhanced its radiosensitizing effect, particularly at lower radiation doses.
    • Combining SR with NA decreased its radiosensitizing effect.
    • Both PENTO and NA demonstrated very low toxicity.

    Conclusions:

    • Pentoxifylline (PENTO) is a promising radiosensitizer with a stronger effect and lower toxicity than SR 2508.
    • The combination of PENTO and nicotinamide (NA) further enhances radiosensitization, especially at lower radiation doses.
    • PENTO represents a potentially valuable and safer option for clinical radiosensitization, either as a standalone agent or in combination therapy.