Related Experiment Video
Updated: Jun 1, 2026
07:32
Porcine Normothermic Isolated Liver Perfusion
Published on: June 9, 2023
Intraperitoneal hyperthermic perfusion (IPHP).
M Deraco1, M Vaglini, M Santinami
1IST NAZL STUDIO & CURA TUMORI,ANAESTHESIOL & INTENS CARE UNIT,I-20133 MILAN,ITALY. IST NAZL STUDIO & CURA TUMORI,DIV GYNAECOL ONCOL,I-20133 MILAN,ITALY.
Oncology Reports
|May 20, 2011
Summary
Intraperitoneal hyperthermic perfusion (IPHP) using CDDP and MMC offers a viable treatment for peritoneal carcinomatosis. This study found IPHP comparable to extensive abdominal surgery regarding complications and toxicity.
Area of Science:
- Oncology
- Surgical Oncology
- Pharmacology
Background:
- Peritoneal carcinomatosis presents a significant challenge in cancer treatment.
- Intraperitoneal hyperthermic perfusion (IPHP) is an emerging therapeutic approach.
Purpose of the Study:
- To evaluate the clinical introduction and outcomes of IPHP with CDDP and MMC for peritoneal carcinomatosis.
- To assess the toxicity and complication rates associated with IPHP.
Main Methods:
- Twenty-six patients with peritoneal carcinomatosis underwent surgical treatment combined with IPHP.
- IPHP solution contained cisplatin (CDDP) at 25 mg/m(2)/l and mitomycin C (MMC) at 3.3 mg/m(2)/l.
- Peritoneal carcinomatosis was staged using the Japanese classification (P1-P3).
Main Results:
- Creatinine and amylase levels were the primary indicators of biological toxicity.
- The surgical complication rate, including two duodenal fistulas, was comparable to extensive abdominal surgery.
- Patient outcomes were assessed in relation to carcinomatosis stage.
Conclusions:
- IPHP with CDDP and MMC is a clinically feasible treatment for peritoneal carcinomatosis.
- The procedure demonstrates an acceptable safety profile regarding toxicity and surgical complications.
- Further research may explore optimizing IPHP protocols for improved patient outcomes.
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