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Updated: Jun 1, 2026
10:52
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Minimal change disease associated with MALT lymphoma
Rahil Kasmani1, Vamsee Priya Marina, Syed Abidi
1Division of Nephrology, Univeristy of Toledo College of Medicine, 3000 Arlington Avenue, Mail Stop 1186, Toledo, OH 43614-2598, USA.
International Urology and Nephrology
|May 20, 2011
Summary
This study details a rare case of kidney marginal zone lymphoma presenting as nephrotic syndrome. The patient responded well to a combination therapy including cyclophosphamide, corticosteroids, and Rituximab.
Area of Science:
- Nephrology
- Oncology
- Pathology
Background:
- Low-grade Extranodal Marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a rare kidney malignancy.
- Minimal change disease (MCD) with nephrotic syndrome is typically associated with Hodgkin's lymphoma, not non-Hodgkin's lymphoma.
Observation:
- A patient presented with nephrotic syndrome, a condition characterized by significant protein in the urine.
Findings:
- Kidney biopsy revealed both marginal zone lymphoma and diffuse epithelial foot process effacement, indicative of MCD.
- The patient demonstrated a significant clinical improvement following treatment.
Implications:
- This case highlights the uncommon association between non-Hodgkin's lymphoma and nephrotic syndrome.
- Effective treatment involved a combination of cyclophosphamide, corticosteroids, and Rituximab, suggesting a potential therapeutic strategy for similar rare presentations.
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