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Connective tissue growth factor (CTGF/CCN2) ELISA: a novel tool for monitoring fibrosis
Amélie Dendooven1, Karin G Gerritsen, Tri Q Nguyen
1Department of Pathology, University Medical Center Utrecht, The Netherlands.
Background:
Connective tissue growth factor (CTGF) has been identified as a key factor in the pathogenesis of diseases with significant fibrosis-related complications such as hepatitis, diabetes and renal transplantation. Increasing evidence shows that CTGF levels in plasma, serum and urine have promising biomarker applicability in these disorders.
Objective:
To present an overview of current knowledge on CTGF in various patient populations and the technical aspects of CTGF measurement by enzyme-linked immunosorbent assay (ELISA).
Method:
We performed a comprehensive literature search by using electronic bibliographic databases.
Conclusion:
CTGF is associated with disease severity parameters and outcome in fibrotic disease and may have diagnostic and prognostic values. However, CTGF ELISA needs standardization.