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Updated: Jun 1, 2026
3D Hydrogel Scaffolds for Articular Chondrocyte Culture and Cartilage Generation
Published on: October 7, 2015
Nanomaterials and hydrogel scaffolds for articular cartilage regeneration
A Hari Reddi1, José Becerra, José A Andrades
1Department of Orthopaedic Surgery, The Lawrence J. Ellison Center for Tissue Regeneration and Repair, School of Medicine, University of California, Davis, Sacramento, California 95817, USA. ahreddi@ucdavis.edu
Abstract:
Osteoarthritis (OA) is a major clinical and scientific challenge. The degradation of articular cartilage in the joints is a common manifestation of painful arthritis. The regeneration of articular cartilage in OA is an unmet clinical need. The assembly of articular cartilage by tissue engineering toward complete regeneration is the goal of most scientists and surgeons. The key ingredients for regeneration are signals, stem cells, and scaffolds. This brief review focuses on the scaffold, with special emphasis on hydrogels and nanomaterials for the assembly of tissue-engineered cartilage, and ultimately leading to the total regeneration of articular cartilage in the joints.
