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Updated: Jun 1, 2026

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
Therapeutic interventions to renin-angiotensin-aldosterone system, and vascular redox state
Nikolaos Koumallos1, Georgios Nteliopoulos, Andreas Paschalis
1Cardiothoracic Department, University Hospital of South Manchester, Greece. koumallosn@yahoo.gr
Abstract:
It is well established that RAS plays a key role in the development of hypertension, cardiovascular and renal disease. On the other hand oxidative stress is a key feature in vascular homeostasis. Many of the cellular effects of Ang II appear to be mediated by ROS generated by NAD(P)H oxidase. In this review, we provide an overview of ROS physiology in human vessels especially in relation with RAS. We also discuss how therapeutic interventions on RAS affect redox signaling in the vascular wall at a clinical level with the discussion of recent patents.
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