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Updated: Jun 1, 2026
Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
Published on: April 8, 2016
Prolactin level is significantly elevated in lesional skin of patients with psoriasis
Ekramy A El-Khateeb1, Nehal M Zuel-Fakkar, Safaa M Eid
1Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. ekramy.elkhateeb@med.asu.edu.eg
Background:
Accumulating data point to a potential role of prolactin in the pathogenesis of psoriasis.
Methods:
We initiated a study including psoriasis patients (n = 15) and healthy volunteers (n = 15) as controls. Psoriasis area and severity index (PASI) score was evaluated, and prolactin levels in serum and blister fluid were assessed by enzyme-linked immunosorbent assay (ELISA).
Results:
Prolactin levels were significantly (P < 0.01) elevated in blister fluid of psoriatic lesional skin. Correlations between PASI score and different serum prolactin levels in lesional and non-lesional skin were insignificant. Significant positive correlations of prolactin level were observed between lesional and non-lesional skin in psoriasis (P < 0.05) and between serum and clinically normal skin in both psoriasis and control subjects (P < 0.05).
Conclusions:
Locally produced prolactin may be involved in the pathogenesis of psoriatic lesions.
