Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Physicochemical and biological properties of nanohydroxyapatite grafted with star-shaped poly(ε-caprolactone).

Journal of biomaterials science. Polymer edition·2022

Same author

In vitro cytotoxic data on Se-methylselenocysteine conjugated to dendritic poly(glycerol) against human squamous carcinoma cells.

Journal of biomaterials science. Polymer edition·2021

Same author

Microfluidic caging lipase in hyperbranched polyglycerol microcapsules for extracorporeal treatment of enzyme pancreatic insufficiency.

Journal of biomaterials science. Polymer edition·2021

Same author

Long term multiple sclerosis drug delivery using dendritic polyglycerol flower-like microspheres.

Journal of biomaterials science. Polymer edition·2019

Same author

Interactions of polyglycerol dendrimers with human serum albumin: insights from fluorescence spectroscopy and computational modeling analysis.

Journal of biomaterials science. Polymer edition·2019

Same author

Biological properties of electrospun cellulose scaffolds from biomass.

Journal of biomaterials science. Polymer edition·2019

Search research articles

Related Experiment Video

Updated: Jun 1, 2026

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Published on: June 15, 2021

Dendronized polyaniline nanotubes for cardiac tissue engineering.

Renata Mendes Moura¹, Alvaro Antonio Alencar de Queiroz

¹Laboratório de Biomateriais, Universidade Federal de Itajubá (UNIFEI), Itajubá-MG, Brazil.

Artificial Organs

|May 21, 2011

Summary

Polyaniline nanotubes functionalized with polyglycerol dendrimers enhance cardiac cell growth and differentiation. This biocompatible nanobiomaterial shows promise for cardiac tissue engineering applications.

More Related Videos

3D Human Myocardial Tissue Generation Using Melt Electrospinning Writing of Polycaprolactone Scaffolds and hiPSC-Derived Cardiac Cells

3D Human Myocardial Tissue Generation Using Melt Electrospinning Writing of Polycaprolactone Scaffolds and hiPSC-Derived Cardiac Cells

Published on: March 28, 2025

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Published on: December 8, 2017

Related Experiment Videos

Last Updated: Jun 1, 2026

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Published on: June 15, 2021

3D Human Myocardial Tissue Generation Using Melt Electrospinning Writing of Polycaprolactone Scaffolds and hiPSC-Derived Cardiac Cells

3D Human Myocardial Tissue Generation Using Melt Electrospinning Writing of Polycaprolactone Scaffolds and hiPSC-Derived Cardiac Cells

Published on: March 28, 2025

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Published on: December 8, 2017

Area of Science:

Biomaterials Science
Nanotechnology
Tissue Engineering

Background:

Nanobiomaterials offer unique properties determined by size and morphology.
Polyaniline nanotubes (PANINTs) are electroactive nanobiomaterials with potential for cardiac tissue engineering.
Improving hydrophilicity is crucial for enhanced biocompatibility and cell proliferation in tissue regeneration.

Purpose of the Study:

To functionalize PANINTs with polyglycerol dendrimers (PGLDs) to improve their biocompatibility and hydrophilic properties.
To evaluate the biocompatibility and cardiomyocyte proliferation on PGLD-modified PANINTs.
To explore the potential of PGLD-PANINTs as a scaffold for cardiac tissue engineering.

Main Methods:

Surface-initiated anionic ring-opening polymerization of glycidol to immobilize PGLDs onto PANINTs.
Characterization of PGLD-PANINTs using X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM).
Assessment of cardiac cell growth, proliferation, and differentiation on PGLD-PANINTs scaffolds, including evaluation of cytotoxicity on Chinese hamster ovary cells.

Main Results:

PGLD-PANINTs exhibited improved hydrophilic properties and non-cytotoxic effects on Chinese hamster ovary cells.
Cardiomyocyte proliferation and growth were observed on the PGLD-PANINTs scaffolds.
Microcurrent stimulation was found to promote cardiac cell differentiation on the PGLD-PANINTs scaffolds.

Conclusions:

PGLD-functionalized PANINTs demonstrate excellent biocompatibility and electroactive properties, making them suitable for cardiac cell culture.
The developed PGLD-PANINTs hold significant potential as a biocompatible, electroactive 3D matrix for cardiac tissue engineering.
This study highlights the successful modification of nanobiomaterials to enhance their utility in regenerative medicine.