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Alterations in brainstem alpha 2 adrenoreceptor activity in pyridoxine-deficient rat model of hypertension
M Viswanathan1, C S Paulose, K J Lal
1Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
Abstract:
Moderate pyridoxine deficiency in adult male Sprague-Dawley rats results in significant hypertension, associated with a general sympathetic stimulation, including an increase in the turnover of norepinephrine in the heart. Treatment of these rats with pyridoxine reversed blood pressure to normal within 24 h. Treatment of pyridoxine-deficient rats with clonidine or alpha-methyl dihydroxyphenylalanine (alpha-methyl DOPA) also reduced the blood pressure of these animals to normal. There was also a significant increase in the Bmax of high and low affinity [3H]p-amino-clonidine binding to crude synaptosomal membrane preparations of the brain stem of deficient rats indicating chronic underexposure of alpha 2 adrenoreceptors to endogenous norepinephrine.