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Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Antiasthma Drugs: Leukotriene Modifiers

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

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Related Experiment Video

Updated: Jun 1, 2026

Methodology for Sputum Induction and Laboratory Processing

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Isoprostanes and asthma.

Judith A Voynow¹, Apparao Kummarapurugu

¹Division of Pediatric Pulmonary and Sleep Medicine, Duke University Medical Center, Durham, NC 27710, USA. judith.voynow@duke.edu

Biochimica Et Biophysica Acta

|May 21, 2011

Summary

This summary is machine-generated.

F₂-isoprostanes (F₂-isoP) are key indicators of oxidative stress in asthma. These compounds, generated during lipid peroxidation, also play a role in the disease's development by influencing lung functions.

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Area of Science:

Biochemistry
Pulmonary Medicine
Oxidative Stress Research

Background:

Isoprostanes are prostaglandin-like molecules formed via non-enzymatic lipid peroxidation of polyunsaturated fatty acids.
Their production is influenced by cellular redox conditions, with F₂-isoprostanes (F₂-isoP) forming under reducing conditions.

Purpose of the Study:

To review the role of F₂-isoP as a marker of oxidative stress in asthma.
To summarize the biological effects of isoprostanes contributing to asthma pathogenesis.

Main Methods:

Literature review focusing on isoprostane biochemistry and their role in asthma.
Analysis of studies investigating F₂-isoP as a biomarker for oxidative stress.
Examination of research on isoprostane-mediated biological effects in the lung.

Main Results:

F₂-isoP are established markers of oxidative stress in pulmonary diseases, particularly asthma.
Isoprostanes act as ligands for prostaglandin receptors and influence various lung cellular processes.
These processes include airway smooth muscle tone, neural secretion, and inflammatory cell function.

Conclusions:

F₂-isoP serve as reliable biomarkers for oxidative stress in asthma.
Isoprostanes contribute significantly to the pathogenesis of asthma through diverse biological mechanisms in the lung.