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Updated: Jun 1, 2026

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Published on: October 14, 2025
The potent anti-inflammatory agent escin does not increase corticosterone secretion and immune cell apoptosis in mice
Leiming Zhang1, Hongsheng Wang, Huaying Fan
1Department of Pharmacology, School of Pharmacy, Yantai University, Yantai, Shandong 264005, PR China.
Abstract:
Escin exerts potent glucocorticoid-like anti-inflammatory effects. The aim of this study was to investigate whether the anti-inflammatory effect of escin is through the up-regulation of glucocorticoids and if escin induces pathological changes in immune organs. Mice were administrated with escin intravenously for 7 days before observing the relevant parameters. The results showed that escin exhibits a potent anti-inflammatory effect, but does not increase corticosterone secretion in mice, and does not increase immune cell apoptosis in the spleen and thymus of mice. These findings suggest that the anti-inflammatory effect of escin is not dependent on the release of corticosterone.
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