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Published on: June 6, 2025
Treatment of 5413 hypertensive patients: a cross-sectional study
M S Paulsen1, J Sondergaard, L Reuther
1Research Unit of General Practice, Institute of Public Health, University of Southern Denmark, Odense. mspaulsen@health.sdu.dk
Insights
Optimal blood pressure (BP) control is insufficient in Danish primary care, with only 29.1% of patients achieving target BP. Most hypertensive patients receive one or two BP-lowering medications, indicating a need for improved treatment strategies.
Area of Science:
- Cardiology
- General Practice
- Public Health
Background:
- Hypertension management is primarily conducted in Danish primary care settings.
- Previous research indicates suboptimal blood pressure (BP) control in 57-79% of hypertensive patients.
- Key factors influencing BP management include antihypertensive drug treatment, patient risk factors, and presence of cardiovascular disease (CVD).
Purpose of the Study:
- To evaluate BP treatment adherence to Danish guidelines (general: <140/90 mmHg; diabetics: <130/80 mmHg).
- To analyze BP control in relation to patient risk factors, CVD, and diabetes status.
- To assess antihypertensive drug prescribing patterns in a primary care population.
Main Methods:
- A cross-sectional study involving 184 general practices and 5413 hypertensive patients in Denmark.
- Data collection included physician-recorded information on risk factors, CVD, and antihypertensive medications.
- Patient-reported data on risk factors were gathered via questionnaires; BP control was the primary outcome measure.
Main Results:
- Only 29.1% of the hypertensive population achieved optimal BP control.
- Among diabetic patients, optimal BP control was achieved by 10.9%, with 38.7% of patients with CVD reaching target BP.
- The majority of patients were treated with one (32.5%) or two (39.0%) antihypertensive drugs; 17.7% of hypertensive diabetics were not on recommended renin-angiotensin system inhibitors.
Conclusions:
- A significant proportion of hypertensive patients in general practice do not achieve optimal BP control.
- Current antihypertensive treatment regimens, often involving one or two drugs, appear insufficient for achieving guideline-recommended BP targets.
- Further optimization of treatment strategies is necessary to improve BP control in hypertensive patients within primary care settings.
Background:
Most hypertensive patients are managed in primary care in Denmark, but previous studies have shown that only 21-43% of hypertensive patients achieve optimal blood pressure (BP) control. Antihypertensive drug treatment, risk factors and cardiovascular disease (CVD) are some of the important factors to consider when optimizing the individual treatment strategy in hypertensive patients.
Objective:
To examine treatment of BP according to Danish guidelines (BP < 140/90 mmHg generally and <130/80 mmHg for diabetics) in a population from general practice in relation to risk factors, CVD and diagnosis of diabetes.
Methods:
A cross-sectional study comprising 184 practices and 5413 hypertensive patients was carried out in Denmark. The general practitioners filled in information on each patient's risk factors, CVD and antihypertensive drug treatment. Patients filled in a questionnaire on risk factors. The outcome measures were optimal BP control according to Danish guidelines and antihypertensive drug treatment.
Results:
Mean patient age was 65.9 years [95% confidence interval (CI): 65.6-66.1]. Optimal BP control was achieved in 29.1% (95% CI: 27.9-30.3) of the study population. Among 842 diabetics with or without CVD, optimal BP control was achieved in 10.9% (95% CI: 8.8-10.3), while 38.7% (35.5-41.9) of patients with CVD achieved optimal BP control. The majority of all patients were treated with 1 (32.5%, 95% CI: 32.5 (31.3-33.8)) or two antihypertensive drugs (39.0%, 95% CI: 38.2-40.8). In hypertensive diabetics, 17.7% were not treated with an angiotensin-converting enzyme inhibitor or angiotensin-receptor blocker.
Conclusion:
In general practice, the proportion of hypertensive patients achieving optimal BP control is inadequate. The majority of hypertensive patients are treated with only one or two antihypertensive drugs.
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