Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatitis C.

J A Cuthbert1

  • 1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-8887.

The American Journal of the Medical Sciences
|May 1, 1990
PubMed
Summary

Hepatitis C virus (HCV) causes chronic post-transfusion hepatitis. Detecting anti-HCV antibodies aids diagnosis, and blood screening may prevent future infections.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hepatitis A: old and new.

Clinical microbiology reviews·2001
Same author

Multiple mechanisms, independent of sterol regulatory element binding proteins, regulate low density lipoprotein gene transcription.

Journal of lipid research·2000
Same author

Wilson's disease. Update of a systemic disorder with protean manifestations.

Gastroenterology clinics of North America·1999
Same author

Sterol-independent, sterol response element-dependent, regulation of low density lipoprotein receptor gene expression.

Journal of lipid research·1998
Same author

Overexpression of cholesterol 7alpha-hydroxylase (CYP7A) in mice lacking the low density lipoprotein (LDL) receptor gene. LDL transport and plasma LDL concentrations are reduced.

The Journal of biological chemistry·1998
Same author

Iron, HFE, and hemochromatosis update.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research·1998

Area of Science:

  • Hepatology
  • Virology
  • Immunology

Background:

  • Hepatitis C virus (HCV) identified as the primary cause of chronic post-transfusion hepatitis.
  • HCV is a single-stranded RNA virus, similar to flaviviruses.
  • Hepatitis E virus (HEV) linked to epidemic, enterically-transmitted non-A, non-B hepatitis.

Purpose of the Study:

  • To summarize current understanding of Hepatitis C virus (HCV) in post-transfusion hepatitis.
  • To review diagnostic markers and therapeutic approaches for HCV infection.
  • To discuss the potential of blood screening for HCV prevention.

Main Methods:

  • Review of existing literature on Hepatitis C virus (HCV) and non-A, non-B hepatitis.
  • Analysis of anti-HCV antibody detection in patients and blood donors.
  • Evaluation of interferon therapy outcomes for chronic hepatitis C.

Main Results:

  • Anti-HCV antibodies are present in up to 90% of chronic non-A, non-B post-transfusion hepatitis patients.
  • HCV antibodies found in 1% of blood donors and implicated donors, plus patients with autoimmune liver disease and hepatocellular carcinoma.
  • Recombinant human alpha-interferon therapy improves aminotransferase levels in ~50% of patients, but relapse is common.

Conclusions:

  • HCV is the main cause of chronic post-transfusion hepatitis, detected via anti-HCV antibodies.
  • HCV infection may impact alcoholic liver disease; its role in fulminant hepatitis and aplastic anemia requires further study.
  • Future blood screening for HCV could significantly reduce post-transfusion hepatitis cases.

Related Experiment Videos