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A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

Hepatitis C

J A Cuthbert1

  • 1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-8887.

The American Journal of the Medical Sciences
|May 1, 1990
PubMed

Insights

Hepatitis C virus (HCV) causes chronic post-transfusion hepatitis. Detecting anti-HCV antibodies aids diagnosis, and blood screening may prevent future infections.

Area of Science:

  • Hepatology
  • Virology
  • Immunology

Background:

  • Hepatitis C virus (HCV) identified as the primary cause of chronic post-transfusion hepatitis.
  • HCV is a single-stranded RNA virus, similar to flaviviruses.
  • Hepatitis E virus (HEV) linked to epidemic, enterically-transmitted non-A, non-B hepatitis.

Purpose of the Study:

  • To summarize current understanding of Hepatitis C virus (HCV) in post-transfusion hepatitis.
  • To review diagnostic markers and therapeutic approaches for HCV infection.
  • To discuss the potential of blood screening for HCV prevention.

Main Methods:

  • Review of existing literature on Hepatitis C virus (HCV) and non-A, non-B hepatitis.
  • Analysis of anti-HCV antibody detection in patients and blood donors.
  • Evaluation of interferon therapy outcomes for chronic hepatitis C.

Main Results:

  • Anti-HCV antibodies are present in up to 90% of chronic non-A, non-B post-transfusion hepatitis patients.
  • HCV antibodies found in 1% of blood donors and implicated donors, plus patients with autoimmune liver disease and hepatocellular carcinoma.
  • Recombinant human alpha-interferon therapy improves aminotransferase levels in ~50% of patients, but relapse is common.

Conclusions:

  • HCV is the main cause of chronic post-transfusion hepatitis, detected via anti-HCV antibodies.
  • HCV infection may impact alcoholic liver disease; its role in fulminant hepatitis and aplastic anemia requires further study.
  • Future blood screening for HCV could significantly reduce post-transfusion hepatitis cases.

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