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Related Experiment Video

Updated: Jun 1, 2026

Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation

Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation

Published on: November 26, 2019

"Tonic" but not "Adie" pupils.

Michael Kelly-Sell¹, Grant T Liu

¹Division of Neuro-Ophthalmology, Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

Journal of Neuro-Ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society

|May 21, 2011

Summary

Tonic pupils, characterized by poor light reaction but near-stimulus constriction, are often misattributed. It is more accurate to refer to the pupillary abnormality as a "tonic pupil," reserving Adie's name for the associated syndrome.

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Area of Science:

Ophthalmology
Neurology

Background:

Tonic pupils exhibit poor pupillary light reflex but normal near response.
The term 'Adie's pupil' is commonly associated with this pupillary abnormality.

Discussion:

A review of Adie's original works indicates he described a syndrome, not the pupillary anomaly itself.
This suggests a potential misattribution in the common nomenclature.

Key Insights:

The pupillary abnormality should be termed 'tonic pupil'.
Adie's name is more appropriately reserved for the syndrome encompassing tonic pupils and absent reflexes.

Outlook:

Clarifying nomenclature enhances diagnostic precision in ophthalmology and neurology.
Promoting accurate terminology aids in distinguishing isolated pupillary defects from broader neurological syndromes.