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Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Real-Time Measurement of the Mitochondrial Bioenergetic Profile of Neutrophils
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Published on: June 2, 2023

Mitochondria in innate immune responses.

A Phillip West1, Gerald S Shadel, Sankar Ghosh

  • 1Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

Nature Reviews. Immunology
|May 21, 2011
PubMed
Summary

Mitochondria are central to the innate immune system, regulating antiviral and antibacterial responses. This review explores their crucial roles beyond metabolism and cell death.

Area of Science:

  • Immunology
  • Cell Biology
  • Mitochondrial Biology

Background:

  • The innate immune system is crucial for mammalian defense.
  • Mitochondria are increasingly recognized for their roles beyond energy production.
  • Emerging evidence highlights mitochondrial involvement in immune signaling and response.

Purpose of the Study:

  • To review the multifaceted roles of mitochondria in innate immunity.
  • To consolidate current understanding of mitochondria as immune signaling platforms.
  • To highlight mitochondria's contribution to antimicrobial and stress-induced immunity.

Main Methods:

  • Literature review of recent research on mitochondria and innate immunity.
  • Synthesis of findings on mitochondrial functions in immune pathways.

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Real-Time Measurement of the Mitochondrial Bioenergetic Profile of Neutrophils
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  • Analysis of mitochondria's role in regulating cellular damage and stress responses.

    • Main Results:

    • Mitochondria act as signaling platforms in innate immune pathways.
    • They contribute to effector responses, including reactive oxygen species generation.
    • Mitochondria regulate antiviral signaling and facilitate antibacterial immunity.
    • Mitochondria are involved in innate immune activation following cellular damage and stress.

    Conclusions:

    • Mitochondria are pivotal hubs in the innate immune system.
    • Their functions extend significantly beyond cellular metabolism and programmed cell death.
    • Mitochondria are integral to mammalian immune defense mechanisms.