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Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients
Published on: September 25, 2018
Cyfra 21-1 - a new tumor-marker for lung-cancer
C Lequaglie1, P Marino, C Maioli
1S PAOLO HOSP,DEPT MED,MILAN,ITALY. S PAOLO HOSP,NUCL SERV MED,MILAN,ITALY.
Oncology Reports
|May 21, 2011
Summary
Serum levels of cytokeratin fragment 19 (CYFRA 21-1) are elevated in lung cancer patients. Combining CYFRA 21-1 with tissue polypeptide antigen (TPA) improves diagnostic sensitivity for lung cancer.
Area of Science:
- Oncology
- Biochemistry
- Clinical Diagnostics
Background:
- Cytokeratin 19 is found in simple epithelia, including the bronchial tree.
- CYFRA 21-1 is a serum assay detecting a fragment of cytokeratin 19.
- Lung cancer diagnosis often relies on multiple biomarkers.
Purpose of the Study:
- To evaluate CYFRA 21-1 serum levels in lung cancer patients.
- To compare CYFRA 21-1 with other tumor markers like CEA, NSE, and TPA.
- To assess the combined diagnostic utility of CYFRA 21-1 and TPA.
Main Methods:
- An immunoradiometric assay (CYFRA 21-1) was used.
- Serum samples from 67 lung cancer patients and 23 healthy controls were analyzed.
- Tumor markers were compared using 95% specificity cut-off values against controls.
Main Results:
- CYFRA 21-1 serum levels were significantly higher in lung cancer patients (p<0.001).
- TPA showed higher sensitivity (49%) than CYFRA 21-1 (40%) alone.
- Combining CYFRA 21-1 and TPA increased sensitivity to 63%.
Conclusions:
- Elevated CYFRA 21-1 is observed in lung cancer, particularly adenocarcinoma.
- CYFRA 21-1 is not exclusively specific for squamous cell carcinoma.
- Combined use of CYFRA 21-1 with TPA or other markers enhances diagnostic and prognostic sensitivity.
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