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Published on: May 9, 2018
Venous thromboembolism after surgery for benign prostatic hyperplasia
1Department of Surgical Sciences, Section of Vascular Surgery, University Hospital, 751 85 Uppsala, Sweden. david.bergqvist@surgsci.uu.se
Surgery for benign prostatic hyperplasia increases deep vein thrombosis risk, especially after open procedures. Heparin can reduce this risk following open surgery, but data on newer methods and transurethral resection is limited.
Area of Science:
- Urology
- Vascular Surgery
- Pharmacology
Background:
- Benign prostatic hyperplasia (BPH) is a common condition in aging men, often requiring surgical intervention.
- Venous thromboembolism (VTE), including deep vein thrombosis (DVT), is a known postoperative complication.
- The comparative risk of VTE across different BPH surgical techniques requires systematic evaluation.
Purpose of the Study:
- To systematically review the incidence of VTE after surgery for benign prostatic hyperplasia.
- To compare VTE risk between open surgery and transurethral resection (TUR) procedures.
- To assess the efficacy of thromboprophylaxis in reducing VTE after BPH surgery.
Main Methods:
- Systematic literature review of studies reporting VTE outcomes after BPH surgery.
- Analysis of DVT risk stratified by surgical approach: open surgery versus transurethral resection.
- Evaluation of available data on thromboprophylaxis (heparin) and antifibrinolytic agents.
Main Results:
- Deep vein thrombosis risk is 2-4 times higher after open surgery compared to transurethral resection for BPH.
- The VTE risk associated with newer transurethral techniques (laser, radiofrequency, heat) remains largely unknown.
- Limited studies suggest heparin thromboprophylaxis effectively reduces postoperative DVT incidence after open BPH surgery.
- Data on thromboprophylaxis following transurethral resection is scarce.
- Antifibrinolytic treatment for bleeding reduction does not appear to elevate thrombosis risk.
Conclusions:
- Open surgery for BPH carries a significantly higher risk of DVT than transurethral resection.
- Further research is needed to establish VTE risks and optimal thromboprophylaxis strategies for newer transurethral BPH procedures.
- Heparin is effective for DVT prevention in open BPH surgery, while antifibrinolytics seem safe regarding thrombosis.
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