Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...

Cross-bridge Cycle

Cross-bridge Cycle

As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.

Cushing Syndrome II: Pathophysiology

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...

Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Neuronal Cell Line Model for Studying Camel Prions.

Pathogens (Basel, Switzerland)·2026

Same author

Limited transmission of cervid prions to nonhuman primates provides insights into the zoonotic potential of chronic wasting disease.

Science advances·2026

Same author

Prion shedding is reduced by chronic wasting disease vaccination.

PLoS pathogens·2026

Same author

Prion shedding is reduced by chronic wasting disease vaccination.

bioRxiv : the preprint server for biology·2025

Same author

PLGA nanoparticles for oral delivery of prion-specific antigen: a novel approach to chronic wasting disease vaccination.

Scientific reports·2025

Same author

Genetic Variation and Strain Dynamics in Chronic Wasting Disease.

Viruses·2025

Search research articles

Related Experiment Video

Updated: Jun 1, 2026

Real-time Quaking-induced Conversion Assay for Detection of CWD Prions in Fecal Material

Real-time Quaking-induced Conversion Assay for Detection of CWD Prions in Fecal Material

Published on: September 29, 2017

Chronic wasting disease.

Sabine Gilch¹, Nandini Chitoor, Yuzuru Taguchi

¹Department of Veterinary Sciences, University of Wyoming, Laramie, WY 82070, USA.

Topics in Current Chemistry

|May 21, 2011

Summary

This summary is machine-generated.

Chronic wasting disease (CWD) is a highly contagious prion illness affecting cervids. Its increasing spread and environmental persistence present significant wildlife management challenges.

More Related Videos

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

Detection of Abnormal Prion Protein by Immunohistochemistry

Detection of Abnormal Prion Protein by Immunohistochemistry

Published on: May 5, 2023

Related Experiment Videos

Last Updated: Jun 1, 2026

Real-time Quaking-induced Conversion Assay for Detection of CWD Prions in Fecal Material

Real-time Quaking-induced Conversion Assay for Detection of CWD Prions in Fecal Material

Published on: September 29, 2017

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

Detection of Abnormal Prion Protein by Immunohistochemistry

Detection of Abnormal Prion Protein by Immunohistochemistry

Published on: May 5, 2023

Area of Science:

Veterinary Pathology
Wildlife Epidemiology
Prion Disease Research

Background:

Chronic wasting disease (CWD) is a fatal prion disease impacting wild and farmed ungulates in North America and South Korea.
CWD has seen significant increases in prevalence and geographical range, with high infection rates in certain deer populations.
The disease is highly contagious among cervids through horizontal transmission via bodily fluids and environmental contamination.

Purpose of the Study:

To review the current understanding of Chronic Wasting Disease (CWD) in ungulates.
To highlight the challenges in managing CWD due to its transmissibility and environmental persistence.
To address the unanswered questions regarding CWD's potential for interspecies transmission and zoonotic risk.

Main Methods:

Literature review and synthesis of existing research on CWD.
Analysis of epidemiological data on CWD prevalence and distribution.
Discussion of prion disease mechanisms and transmission routes.

Main Results:

CWD is the most contagious known prion disease, with extensive horizontal transmission.
Environmental contamination and animal migration facilitate CWD spread, making it difficult to control.
While highly transmissible among cervids, interspecies transmission appears restricted, but not fully evaluated for all species.

Conclusions:

Effective containment of CWD requires further research into its molecular biology, pathology, and transmission dynamics.
Understanding species restrictions and developing preclinical diagnostic tools are crucial for managing this prion disease.
The zoonotic potential of CWD remains an open question, necessitating continued investigation.