Solid-phase parallel synthesis of a tetrahydroindazolone library containing three unique core skeletons
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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Jonghoon Kim1, Heebum Song, Seung Bum Park
1Department of Chemistry, Seoul National University, 151-747 Seoul, South Korea.
Abstract:
We have developed a practical strategy for the regioselective synthesis of a 1-(hetero)aryl-3-substituted tetrahydroindazolone library. The condensation of in situ generated arylhydrazine on solid supports with 2-acylcyclohexane-1,3-diones ensured the efficiency of solid-phase parallel synthesis. In addition, we introduced three unique core skeletons containing nitrophenyl, anilyl, and pyridyl groups to maximize the molecular diversity through a diverse display of polar surface area in 3D chemical space. A 162-membered drug-like tetrahydroindazolone library was constructed in an average purity of 92% without further purification.
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