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Collared crypts in irradiated small intestine.

K E Carr1, T L Hayes, B Abbas

  • 1Department of Anatomy, Queen's University of Belfast.

Journal of Submicroscopic Cytology and Pathology
|April 1, 1990
PubMed
Summary
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Heavy ion radiation significantly alters mouse intestinal crypt mouths, creating larger openings with collars. This damage differs from X-irradiation effects and may necessitate redefining intestinal structures based on subepithelial vessels.

Area of Science:

  • Gastroenterology
  • Radiation Biology
  • Histopathology

Background:

  • Crypt counting assesses radiation damage in the small intestine.
  • Little research exists on crypt mouth surface contours after irradiation.
  • Crypts of Lieberkuhn are known to be radiosensitive.

Purpose of the Study:

  • To characterize the structural changes in mouse crypt mouths after heavy ion irradiation.
  • To investigate the relationship between radiation type, LET, and observed crypt mouth morphology.
  • To explore potential redefinitions of intestinal structures based on observed radiation-induced changes.

Main Methods:

  • Microscopic examination of mouse small intestine crypt mouths.
  • Irradiation of mice with neon, silicon, and iron ions.

Related Experiment Videos

  • Comparison of crypt mouth morphology between irradiated and control groups.
  • Analysis of crypt mouth diameter and the incidence of collared structures.

    • Main Results:

    • Control mouse crypt mouths are approximately 5 microns in diameter.
    • Heavy ion irradiation enlarged crypt mouths up to 10 microns, forming distinct collars.
    • Iron ion irradiation produced the most pronounced collars.
    • Collared crypts were not observed after single doses of X-irradiation.
    • The size and incidence of collared crypts correlated with the linear energy transfer (LET) of the ion beam.

    Conclusions:

    • Heavy ion irradiation causes unique morphological changes in mouse intestinal crypt mouths, distinct from X-irradiation.
    • The observed collared crypts represent localized damage and may warrant a redefinition of intestinal crypt and villus structures.
    • The findings suggest a correlation between radiation LET and the severity of crypt mouth damage.