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[Constituents and bioactivities of Lamiophlomis rotata]
Yanjun Hao1, Lin Li, Chen Chen
1Liaoning Institute for Food and Drug Control, Shenyang 110023, China.
Objective:
To investigate the chemical constituents from Lamiophlomis rotata and the bioactivities of 8-epideoxyloganic acid.
Method:
The constituents were isolated by using a combination of various chromatographic techniques including column chromatography over ployamide, silica gel and Sephadex LH-20. Structures of the isolates were identified by spectroscopic data analysis. Bioactivities were screened by using models in vivo.
Result:
Five constituents were isolated. 8-epideoxyloganic acid was isolated for the first time in L. rotata and also in lamioplomis genus. 8-epideoxyloganic acid could significantly inhibit aectic acid-induced twisting times and slower the time of homeostatsis, also inhibit xylene-induced ear edema in mice.
Conclusion:
8-epideoxyloganic acid possesses bioactivities of analgesia, homeostasis and anti-inflammatory.