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Related Concept Videos

Diffusion01:12

Diffusion

Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
Diffusion01:21

Diffusion

Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
Types of Damping01:20

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If the amount of damping in a system is gradually increased, the period and frequency start to become affected because damping opposes, and hence slows, the back and forth motion (the net force is smaller in both directions). If there is a very large amount of damping, the system does not even oscillate; instead, it slowly moves toward equilibrium. In brief, an overdamped system moves slowly towards equilibrium, whereas an underdamped system moves quickly to equilibrium but will oscillate about...
Damped Oscillations01:07

Damped Oscillations

In the real world, oscillations seldom follow true simple harmonic motion. A system that continues its motion indefinitely without losing its amplitude is termed undamped. However, friction of some sort usually dampens the motion, so it fades away or needs more force to continue. For example, a guitar string stops oscillating a few seconds after being plucked. Similarly, one must continually push a swing to keep a child swinging on a playground.
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Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model

Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the concentration...
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Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...

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An Analog Macroscopic Technique for Studying Molecular Hydrodynamic Processes in Dense Gases and Liquids
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Diffusion over a fluctuating barrier in underdamped dynamics.

Jun-Wen Mao1, Cai-Wan Shen

  • 1Department of Physics, Huzhou Teachers College, Huzhou 313000, People's Republic of China. jwmao@hutc.zj.cn

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|May 24, 2011
PubMed
Summary
This summary is machine-generated.

We studied how particles move over changing barriers using a Langevin model. Barrier fluctuations significantly impact particle diffusion and crossing dynamics, especially when correlations are present.

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Area of Science:

  • Physics
  • Physical Chemistry
  • Statistical Mechanics

Background:

  • Thermally activated diffusion is fundamental to many physical and chemical processes.
  • Understanding barrier crossing dynamics is crucial in fields like reaction kinetics and materials science.
  • Fluctuating barriers introduce complexities not present in static systems.

Purpose of the Study:

  • To investigate the effects of a fluctuating barrier on the diffusion of particles in underdamped dynamics.
  • To analyze the role of barrier fluctuation correlations in thermally activated diffusion.
  • To provide exact solutions for the moments of the diffusion process.

Main Methods:

  • Application of a Langevin model with additive and multiplicative noises.
  • Characterization of barrier fluctuations using Gaussian colored noise with exponential correlation.
  • Derivation of exact solutions for the first and second moments.
  • Direct numerical simulations to determine asymptotic probabilities.

Main Results:

  • Exact analytical solutions for the first and second moments of the diffusion process were obtained.
  • Direct simulations confirmed the theoretical predictions for barrier crossing probability.
  • The correlation properties of the fluctuating barrier were found to be critically important.
  • Underdamped dynamics significantly influence the diffusion process over fluctuating barriers.

Conclusions:

  • The correlation of barrier fluctuations is a key factor governing the dynamics of particle diffusion.
  • The Langevin model provides a robust framework for studying complex diffusion phenomena.
  • This research offers insights into systems with dynamic energy landscapes.