Related Experiment Video
Updated: Jun 1, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
Published on: July 16, 2014
Neural dynamics in parkinsonian brain: the boundary between synchronized and nonsynchronized dynamics
Choongseok Park1, Robert M Worth, Leonid L Rubchinsky
1Department of Mathematical Sciences and Center for Mathematical Biosciences, Indiana University Purdue University Indianapolis, Indianapolis, Indiana 46202, USA.
None:
Synchronous oscillatory dynamics is frequently observed in the human brain. We analyze the fine temporal structure of phase-locking in a realistic network model and match it with the experimental data from Parkinsonian patients. We show that the experimentally observed intermittent synchrony can be generated just by moderately increased coupling strength in the basal ganglia circuits due to the lack of dopamine. Comparison of the experimental and modeling data suggest that brain activity in Parkinson's disease resides in the large boundary region between synchronized and nonsynchronized dynamics. Being on the edge of synchrony may allow for easy formation of transient neuronal assemblies.
More Related Videos
Related Concept Videos
Neural Regulation
Parkinson Disease ll: Pathophysiology
Parkinson's Disease: Overview
Alterations in Muscle Tone ll
Parkinson Disease l: Introduction
Alterations in Muscle Tone lll

