Related Experiment Video
Updated: Aug 18, 2026

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
Protein kinase activity associated with a cell cycle regulated, membrane-bound Epstein-Barr virus induced early
1Department of Microbiology, Georgetown University Medical School, Washington, D.C. 20007.
Abstract:
An Epstein-Barr virus protein associated with the restricted component of the early antigen complex was characterized in this study. This protein was of particular interest because of its homology to polyoma middle T antigen and to the product of the bcl-2 oncogene. The results from this study reveal that this protein had a number of unusual properties in comparison with other polypeptides associated with the early antigen complex. For example, the synthesis of this membrane-associated antigen was regulated by the cell cycle, and its expression was compatible with cell survival. Functional studies reveal that immunoprecipitates containing this protein exhibited a threonine-serine-specific protein kinase activity. The results suggest that this protein might function in both the immortalization and replication cycles of this virus.
Related Concept Videos
Positive Regulator Molecules
Negative Regulator Molecules
Positive Regulator Molecules
Inhibition of Cdk Activity
Mitogens and the Cell Cycle
MAPK Signaling Cascades

