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Collection of Frozen Rodent Brain Regions for Downstream Analyses
Published on: April 23, 2020
Three brain collections for comparative neuroanatomy and neuroimaging
Karl Zilles1, Katrin Amunts, Jeroen B Smaers
1Institute of Neuroscience and Medicine INM-2, Research Centre Jülich, Jülich, Germany.
Annals of the New York Academy of Sciences
|May 24, 2011
Summary
Preserving human brain histological sections is crucial for understanding evolution and brain structure. This review details important collections and their research applications in neuroscience and medicine.
Area of Science:
- Neuroscience
- Evolutionary Biology
- Anthropology
Background:
- Increasing extinction rates risk losing vital evolutionary and anthropological data.
- Histological brain sections are essential for neurobiological and medical research.
- Complete, serially sectioned human brains across ontogenetic stages are vital for research.
Purpose of the Study:
- To support the preparation, preservation, and curation of histological brain section collections.
- To disseminate information on these collections within the neuroscience community.
- To make these valuable research collections publicly available.
Main Methods:
- Detailed account of the Stephan, Zilles, and Zilles-Amunts collections.
- Description of cell body- and myelin-stained histological preparations.
- Review of past and recent research utilizing these collections.
Main Results:
- Histological sections enable microstructural and anatomical evaluations of neuroimaging data.
- The Stephan, Zilles, and Zilles-Amunts collections offer a detailed resource.
- Research using these collections enhances understanding of primate brain evolution and human brain organization.
Conclusions:
- The preservation and accessibility of histological brain collections are paramount for scientific advancement.
- These collections are invaluable for studying brain evolution and human brain structure.
- Continued research using these resources will deepen our understanding of the brain.
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