Related Experiment Video
Updated: Jun 1, 2026

09:33
Cardiac Muscle Cell-based Actuator and Self-stabilizing Biorobot - Part 2
Published on: May 9, 2017
Potential mechanisms for muscle-powered cardiac support.
1Cardiovascular Institute, Allegheny General Hospital, Pittsburgh, PA 15212, USA. trumble@wpahs.org
Artificial Organs
|May 24, 2011
Summary
This study explores using skeletal muscle power for tether-free cardiac assistance via a mechanical prosthesis. Six novel mechanisms are presented to deliver this hydraulic energy to the bloodstream, minimizing complications.
Area of Science:
- Biomedical Engineering
- Cardiovascular Devices
- Biomechanical Engineering
Background:
- Ventricular assist devices (VADs) offer long-term circulatory support.
- Skeletal muscle actuation presents a promising approach for tether-free VADs, avoiding percutaneous drivelines.
- Existing VADs often have complications due to blood-contacting surfaces.
Purpose of the Study:
- To present novel mechanisms for delivering biomechanical energy from skeletal muscle to the bloodstream for VAD function.
- To develop a system that harnesses the power of the latissimus dorsi muscle for hydraulic energy transmission.
- To minimize blood-contacting surfaces in VAD designs to reduce thromboembolic complications.
Main Methods:
- Development of a mechanical prosthesis to collect energy from the latissimus dorsi muscle.
- Design and conceptualization of six prospective mechanisms for hydraulic energy delivery to the bloodstream.
- Evaluation of mechanisms for their potential to eliminate blood-contacting surfaces.
Main Results:
- A mechanical prosthesis capable of collecting and transmitting skeletal muscle energy as hydraulic power was developed.
- Six distinct mechanisms were proposed for blood pumping applications.
- Five of the proposed mechanisms successfully eliminate direct blood-contacting surfaces.
Conclusions:
- Biomechanical actuation using skeletal muscle is a viable strategy for advanced VADs.
- The presented mechanisms offer potential solutions for efficient and safer VAD energy delivery.
- Minimizing blood-contacting surfaces is crucial for reducing VAD-related thromboembolic complications.
Related Concept Videos
Specialized Characteristics of Cardiac Muscles
The primary role of cardiac muscles is to propel blood throughout the cardiovascular system. The cardiac muscle cells, or cardiomyocytes, exhibit specialized characteristics that allow them to perform this function.
Cardiac muscle cells are smaller than skeletal muscles, averaging 10–20 mm in diameter and 50–100 mm in length. However, they have large energy demands for continuous contraction and relaxation. This energy is almost exclusively derived from aerobic metabolism of energy reserves in...
Cardiac muscle cells are smaller than skeletal muscles, averaging 10–20 mm in diameter and 50–100 mm in length. However, they have large energy demands for continuous contraction and relaxation. This energy is almost exclusively derived from aerobic metabolism of energy reserves in...
Structure of Cardiac Muscles
Cardiac muscle, or myocardium, is a specialized type of muscle found exclusively in the heart. Its unique structural and functional characteristics enable the heart to perform its vital role of pumping blood throughout the body continuously and rhythmically. The cardiac muscle cells, or cardiomyocytes, possess an endomysium and perimysium but do not have an epimysium.
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
Pathophysiology of Cardiac Performance
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
Energy Supply for Muscle Contraction
Skeletal muscle fibers have the unique ability to switch between rest and contraction states, using different sources of ATP for energy. The contraction cycle and Ca2+ transport back into the sarcoplasmic reticulum for relaxation require significant ATP. However, the ATP reserves in muscle fibers are limited and can only sustain contractions for a few seconds. Additional ATP production becomes necessary for prolonged contractions. As a result, muscle fibers generate ATP through various sources,...
Motor Unit Stimulation
When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
Mechanism of Breathing III: The Accessory Muscles
The Role of Accessory Muscles in the Respiratory System
The respiratory system is a complex network that relies on primary respiratory muscles like the diaphragm, but also involves accessory muscles to enhance lung expansion and airflow during both inhalation and exhalation.
Enhancing Inhalation with Accessory Muscles:
Accessory muscles such as the sternocleidomastoid, scalene, intercostal, and abdominal muscles are crucial when additional respiratory effort is required, such as during deep...
The respiratory system is a complex network that relies on primary respiratory muscles like the diaphragm, but also involves accessory muscles to enhance lung expansion and airflow during both inhalation and exhalation.
Enhancing Inhalation with Accessory Muscles:
Accessory muscles such as the sternocleidomastoid, scalene, intercostal, and abdominal muscles are crucial when additional respiratory effort is required, such as during deep...

