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Updated: Jun 1, 2026

Chronic Social Defeat Stress in Early Adolescent Male Mice
Published on: January 24, 2025
Risk for suicidal thoughts and behavior after childhood sexual abuse in women and men
Saaniya Bedi1, Elliot C Nelson, Michael T Lynskey
1Department of Psychiatry, Midwest Alcoholism Research Center, Washington University School of Medicine, St. Louis, MO, USA.
Abstract:
Earlier studies have found an elevated risk for psychopathology and suicidal behavior associated with childhood sexual abuse (CSA); however, the degree to which risk is mediated by depression and posttraumatic stress disorder (PTSD) in women and men remains unclear. We examined these issues in data from a family study of childhood maltreatment (N = 2,559). We found significant CSA-associated risk for depression, PTSD, and suicidal behavior for women and men. In survival analyses controlling for these disorders, we observed persistent but somewhat reduced CSA-associated risk for suicidal ideation and suicide attempt. Our findings suggest that these disorders partially mediate CSA-associated risk.
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