Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vaccine effectiveness of mRNA-1345 against RSV-associated hospitalization and medically attended acute respiratory illness among US veterans, 2025-2026.

Vaccine·2026
Same author

Exposure to coal-fired power plant emissions, unconventional natural gas development, and salivary miRNA profiles and asthma in children.

Environmental research·2026
Same author

Leveraging Artificial Intelligence in Allergy, Asthma, and Immunology With Environmental Exposures.

Allergy·2026
Same author

Blood mitochondrial heteroplasmic variants and cognitive performance in late midlife: REGARDS study.

BMC neurology·2026
Same author

The association between PM<sub>2.5</sub> components and cognitive decline: the impact of measurement error correction.

Environmental research·2026
Same author

Life-course Psychosocial Adversity and Biological Aging in the Hispanic Community Health Study / Study of Latinos: A Life-course Model Analysis.

Research square·2026

Related Experiment Video

Updated: Jun 1, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

Ambient pollutants, polymorphisms associated with microRNA processing and adhesion molecules: the Normative Aging

Elissa H Wilker1, Stacey E Alexeeff, Helen Suh

  • 1Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA, USA. ewilker@bidmc.harvard.edu

Environmental Health : a Global Access Science Source
|May 24, 2011
PubMed
Summary

Exposure to fine particulate matter (PM2.5) air pollution over seven days is linked to increased cardiovascular risk markers. Genetic variations in microRNA processing may influence these pollution-related cardiovascular effects.

More Related Videos

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment
06:48

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment

Published on: April 29, 2022

Related Experiment Videos

Last Updated: Jun 1, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment
06:48

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment

Published on: April 29, 2022

Area of Science:

  • Environmental Health Sciences
  • Cardiovascular Disease Epidemiology
  • Molecular Epidemiology

Background:

  • Particulate air pollution is a known risk factor for cardiovascular disease, but critical exposure windows and sources remain unclear.
  • MicroRNAs (miRNAs) play a role in cardiovascular regulation, and their processing gene polymorphisms may affect susceptibility to air pollution.
  • Soluble intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) are biomarkers of endothelial dysfunction and cardiovascular risk.

Purpose of the Study:

  • To investigate the association between longer averaging times of air pollutants (PM2.5, black carbon, sulfates) and levels of sICAM-1 and sVCAM-1.
  • To determine if stationary and mobile sources contribute differently to these associations.
  • To examine whether single nucleotide polymorphisms (SNPs) in miRNA-processing genes modify the relationship between air pollution exposure and cardiovascular biomarkers.

Main Methods:

  • Longitudinal study measuring sICAM-1 and sVCAM-1 from 1999-2008, matched with air pollution data (PM2.5, black carbon, sulfates).
  • Selection of 17 SNPs in five miRNA-processing genes.
  • Application of mixed-effects models with repeated measures to analyze pollutant effects, SNP interactions, and genetic associations under recessive inheritance models.

Main Results:

  • A seven-day moving average of PM2.5 was associated with significantly higher sICAM-1 and sVCAM-1 levels.
  • Seven-day moving averages of sulfates showed a significant association with higher sICAM-1 and a suggestive association with sVCAM-1.
  • No significant associations were found for black carbon. Homozygous carriers of the rs1062923 SNP exhibited lower sICAM-1 and sVCAM-1 levels in relation to PM2.5 exposure, even after multiple comparisons adjustment.

Conclusions:

  • Longer-term (seven-day) exposure to PM2.5 and sulfates is associated with increased levels of cardiovascular risk biomarkers sICAM-1 and sVCAM-1.
  • Genetic variations in miRNA-processing genes, specifically the rs1062923 polymorphism, may modulate the adverse cardiovascular effects of PM2.5 exposure.
  • These findings highlight the importance of considering specific pollutant averaging times and genetic susceptibility in understanding air pollution's impact on cardiovascular health.