[The comparative study on high field MRI and pathology of Alzheimer's disease transgenic mice]

To observe and investigate the neuroimaging characters in early progression of transgenic Alzheimer's disease (AD) mice model, and make sure the diagnosis value of 7.0 T high field magnetic resonance microimaging (MRMI).

APP/PS-1 transgenic mice aged 3, 6, 9 months and the same aged wild type mice were each divided into 6 groups (6 mice in every groups) based on age. The mice brains were scaned with 7.0T high magnetic field MR. Then the mice were killed. The Aβ immunohistochemistry examination was analyzed in the mice brains specimens, and pathological changes were in comparison with the T(2) weighted imaging in the mice brains.

There were a few Aβ plaques in the brains of 6 months APP/PS-1 transgenic mice, while Aβ plaques were increased both in number and volume in the cerebral cortex and hippocampus of 9 months AD mice. The brains of APP/PS-1 double transgenic mice of 3, 6 months and the control group mice were not showed intensity loss on T(2) weighted MR images, while the signal intensity loss was visualized in the cerebral cortex and hippocampus of 9 months AD mice.

7.0T high magnetic field MR could display Aβ plaques in the brains of APP/PS-1 double transgenic mice of 9 months and it is helpful to diagnosis early AD.