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Updated: Jun 1, 2026

Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome

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Published on: September 27, 2024

[The correlation between hyperinsulinemia and pulse wave velocity].

Fu-Sheng Fang¹, Hui Tian, Chun-Lin Li

¹Department of Geriatric Endocrinology, Chinese PLA General Hospital, Beijing 100853, China.

Zhonghua Nei Ke Za Zhi

|May 24, 2011

Summary

Hyperinsulinemia (high insulin levels) is linked to arteriosclerosis (artery hardening) in a Beijing community study. Individuals with hyperinsulinemia exhibited higher pulse wave velocity, indicating stiffer arteries and increased cardiovascular risk.

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Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome

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Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness

Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness

Published on: May 3, 2018

Area of Science:

Cardiovascular Health
Metabolic Syndrome
Vascular Biology

Context:

Arteriosclerosis poses a significant global health burden, associated with increased cardiovascular morbidity and mortality.
Hyperinsulinemia, a condition of elevated insulin levels, is increasingly recognized as a potential contributor to vascular dysfunction.
Understanding the interplay between metabolic status and vascular health is crucial for developing effective preventive strategies.

Purpose:

To investigate the association between hyperinsulinemia and arteriosclerosis in a Chinese population.
To evaluate the relationship between insulin levels, glucose metabolism, and arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV).
To identify hyperinsulinemia as a potential risk factor for arteriosclerosis.

Summary:

A study of 1046 individuals in Beijing revealed that subjects with hyperinsulinemia (HIns) had significantly higher baPWV compared to those with normoinsulinemia (NIns) across different glucose tolerance statuses.
The prevalence of cardiovascular risk factors was notably higher in the HIns group.
Multiple logistic regression confirmed hyperinsulinemia as an independent risk factor for arteriosclerosis, with an odds ratio of 1.91 (95% CI: 1.169–3.105).

Impact:

This research highlights hyperinsulinemia as a critical risk factor for arteriosclerosis, independent of glucose metabolism status.
Findings underscore the importance of managing insulin levels to mitigate vascular disease progression.
The study provides valuable insights for public health initiatives aimed at preventing cardiovascular diseases in at-risk populations.