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Treatment Resistant Cancers

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

Treatment Resistent Cancers

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

What is Cancer?

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...

What is Cancer?

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...

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Related Experiment Video

Updated: Jun 1, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Supportive care for children with cancer.

Marianne D van de Wetering¹, Netteke Y N Schouten-van Meeteren

¹Emma Children's Hospital, Amsterdam, The Netherlands. m.d.vandewetering@amc.uva.nl

Seminars in Oncology

|May 24, 2011

Summary

Optimal supportive care improves survival rates for children with cancer. Key aspects include managing chemotherapy side effects like neutropenia, infections, and pain, alongside integrating palliative care services.

Area of Science:

Pediatric Oncology
Supportive Care
Cancer Treatment

Background:

Childhood cancer survival rates exceed 75% in developed countries.
Intensified cancer treatments lead to significant side effects, including myelosuppression and infection.
Aggressive chemotherapy presents a 40% risk of febrile episodes during neutropenia.

Purpose of the Study:

To outline optimal supportive care strategies for children undergoing cancer treatment.
To address the management of common side effects and complications.
To emphasize the role of palliative care in pediatric oncology.

Main Methods:

Review of current supportive care guidelines and practices.
Discussion of evidence-based management for neutropenia, infections, nausea, vomiting, and pain.

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Last Updated: Jun 1, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Integration of palliative care principles and psychosocial support.

Main Results:

Intravenous broad-spectrum antibiotics are recommended for neutropenic patients.
Central venous catheters in children are associated with infection and thrombosis risks.
Multidisciplinary and palliative care approaches are crucial for symptom management and psychosocial well-being.

Conclusions:

Optimal supportive care is essential for managing side effects and improving outcomes in pediatric cancer patients.
Palliative care should be integrated early and continuously throughout the treatment journey.
A multidisciplinary approach addressing physical, psychosocial, and bereavement needs is vital.