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Related Experiment Video

Updated: Jun 1, 2026

Chronic Constriction Injury of the Distal Infraorbital Nerve (DIoN-CCI) in Mice to Study Trigeminal Neuropathic Pain
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Interdigital neuralgia.

Paul G Peters1, Samuel B Adams, Lew C Schon

  • 1Department of Orthopaedic Surgery, Foot and Ankle Service, Union Memorial Hospital, Baltimore, MD 21218, USA.

Foot and Ankle Clinics
|May 24, 2011
PubMed
Summary
This summary is machine-generated.

Interdigital neuralgia, common in older women, often requires surgery despite initial nonoperative treatments. Dorsal incision excision is preferred for better outcomes, though results vary.

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Area of Science:

  • Orthopedics
  • Podiatry
  • Neurology

Background:

  • Interdigital neuralgia is a common condition, particularly affecting women and individuals in their sixth decade.
  • While nonoperative treatments offer initial relief, a majority of patients eventually opt for surgical intervention.
  • Surgical excision is a common treatment, with historical descriptions dating back to the 19th century.

Purpose of the Study:

  • To review the epidemiology, treatment, and surgical outcomes of interdigital neuralgia.
  • To highlight the preference for a dorsal incision approach in surgical management.
  • To provide an overview of patient outcomes following surgical intervention.

Main Methods:

  • Literature review of interdigital neuralgia, focusing on prevalence, demographics, and treatment modalities.
  • Analysis of nonoperative management strategies including shoe modifications, orthotics, and injections.
  • Evaluation of surgical outcomes, comparing dorsal and plantar incision approaches.

Main Results:

  • Interdigital neuralgia shows a 4- to 15-fold increased prevalence in women, with a mean age of presentation in the sixth decade.
  • Nonoperative treatments provide relief for many, but 60% to 70% of patients ultimately require surgery.
  • Surgical outcomes are generally satisfactory, with reported excellent or good results ranging from 51% to 93%.

Conclusions:

  • Surgical excision, preferably via a dorsal approach to avoid plantar scarring, is a common and often effective treatment for interdigital neuralgia.
  • While outcomes are frequently positive, patient expectations should be managed due to variability in results.
  • Further research may refine surgical techniques and improve long-term patient satisfaction.