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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

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Antiangiogenic agents and endothelin antagonists in advanced castration resistant prostate cancer

M Merino1, A Pinto, R González

  • 1Medical Oncology Department, University Hospital La Paz, Madrid, Spain. mariamesal@gmail.com

European Journal of Cancer (Oxford, England : 1990)
|May 24, 2011
PubMed

Insights

Treatment options for castration-resistant prostate cancer are limited. Antiangiogenic agents, including vascular endothelial growth factor inhibitors, show promise with high response rates and manageable toxicity.

Area of Science:

  • Oncology
  • Medical Research

Background:

  • Prostate cancer therapy has advanced, yet treatment for castration-resistant disease remains limited.
  • Current chemotherapy options offer minimal improvement over existing standards.
  • Antiangiogenic agents present a promising avenue with consistent, positive outcomes.

Purpose of the Study:

  • To review therapeutic angiogenesis inhibitors for metastatic castration-resistant prostate cancer.
  • To highlight agents demonstrating high response rates and manageable toxicity.

Main Methods:

  • Review of recent studies on antiangiogenic agents in prostate cancer.
  • Categorization of therapeutic angiogenesis inhibitors.

Main Results:

  • Antiangiogenic agents show consistent results in metastatic castration-resistant prostate cancer.
  • These agents demonstrate high response rates and manageable toxicity.
  • Key agents include vascular endothelial growth factor inhibitors, tyrosine kinase inhibitors, antiangiogenic and immunomodulatory agents, and endothelin receptor antagonists.

Conclusions:

  • Antiangiogenic agents are a significant therapeutic option for metastatic castration-resistant prostate cancer.
  • Further research into these agents may improve patient outcomes.

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