Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

Cognitive Development During Adulthood

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...

Aging

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

Piaget's Stage 1 of Cognitive Development

Piaget's Stage 1 of Cognitive Development

The sensorimotor stage, the initial phase of Jean Piaget's theory of cognitive development, spans the first two years of a child's life. During this period, infants actively engage with their surroundings, building cognitive awareness through direct interaction with the world. This interaction is primarily based on sensory perception and motor actions, allowing infants to gradually understand basic physical properties and predict how objects interact within their environment.
Exploration...

Alzheimer Disease l: Introduction

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...

Major Somatic Sensory Pathways

Major Somatic Sensory Pathways

Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the posterior columns...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Behavioral and functional characterization of early-stage Parkinson's disease models reveals attentional deficits and circuit-level connectivity alterations.

Experimental neurology·2026

Same author

Long-term inhibition of lysosomal glucocerebrosidase activity promotes GPX4 stability and inhibits ferroptosis in dopaminergic neurons.

Cell death & disease·2026

Same author

A case of monotherapy with intracerebroventricular anaerobic dopamine allows complete control of Parkinson's disease symptoms.

Journal of Parkinson's disease·2026

Same author

Body placement of inertial measurement units differentially affects physical activity assessment accuracy in drug-naïve Parkinson's disease.

Scientific reports·2026

Same author

Energy Stress-Induced Neuroprotection Against Ferroptosis in Dopaminergic Neurons.

Journal of neurochemistry·2026

Same author

Ultrafine particles induce ferroptosis-like stress features in human dopaminergic LUHMES cells via the p53/xCT/GSH/cGPx4 axis.

Toxicology in vitro : an international journal published in association with BIBRA·2026

Search research articles

Related Experiment Video

Updated: Jun 1, 2026

Behavioral Assessment of the Aging Mouse Vestibular System

Behavioral Assessment of the Aging Mouse Vestibular System

Published on: July 11, 2014

Deficit of sensorimotor integration in normal aging.

Adrian Degardin¹, David Devos, François Cassim

¹Université Lille-Nord de France, CHRU de Lille, Neurophysiologie Clinique, Hôpital Roger Salengro, F-59037 Lille Cedex, France.

Neuroscience Letters

|May 24, 2011

Summary

Aging reduces sensorimotor integration, particularly the long-latency influence of proprioceptive inputs on motor cortex excitability. This age-related decline in afferent-induced facilitation (AIF) and long-latency afferent inhibition (LAI) impacts motor control.

More Related Videos

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration

Published on: June 18, 2018

A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease

A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease

Published on: June 13, 2025

Related Experiment Videos

Last Updated: Jun 1, 2026

Behavioral Assessment of the Aging Mouse Vestibular System

Behavioral Assessment of the Aging Mouse Vestibular System

Published on: July 11, 2014

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration

Published on: June 18, 2018

A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease

A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease

Published on: June 13, 2025

Area of Science:

Neuroscience
Gerontology
Motor Control

Background:

Sensorimotor performance naturally declines with advancing age.
Understanding age-related changes in sensorimotor integration is crucial for addressing functional impairments.

Purpose of the Study:

To investigate age-related alterations in sensorimotor integration.
To determine how proprioceptive inputs influence motor cortex excitability across different age groups.

Main Methods:

Utilized transcranial magnetic stimulation (TMS) conditioned with peripheral nerve stimulation.
Measured motor cortex excitability, including motor thresholds, intracortical inhibition/facilitation, short- and long-latency afferent inhibition (SAI, LAI), and afferent-induced facilitation (AIF).

Main Results:

Elderly individuals exhibited a significant decrease in the long-latency influence of proprioceptive inputs on motor cortex (M1) excitability.
The study observed a loss of afferent-induced facilitation (AIF) and long-latency afferent inhibition (LAI) in older adults.
Short-latency afferent inhibition (SAI), motor thresholds, and intracortical inhibition/facilitation remained unaffected by age.

Conclusions:

Age-related sensorimotor decline is associated with reduced influence of proprioceptive inputs on motor cortex excitability at longer intervals.
This impairment may involve higher-order cortical areas and contributes to decreased sensorimotor performance in the elderly.