[Clinico-immunologic parallels in evaluating the treatment of multiple sclerosis]

Certain immunological parameters were examined over time in 54 patients afflicted with multiple sclerosis. Nonhormonal multimodality treatment methods including immunomodulatory remedies and corticosteroid hormones were employed. The total counts of T and B lymphocytes as well as their functional activity were found to be related to the disease stage. The pattern of changes in the main factors of immune responsiveness influenced by different types of therapy was established to be inconclusive. Based on an analysis of the clinico-paraclinical parameters it is concluded that conventional multimodality therapy including the use of immunomodulators may be administered both during disease remission and, in some cases, during its exacerbation.