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Updated: Jun 1, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
Published on: November 10, 2013
Genotoxicity of the copper antineoplastic coordination complexes casiopeinas
J Serment-Guerrero1, P Cano-Sanchez, E Reyes-Perez
1Departamento de Biología, Instituto Nacional de Investigaciones Nucleares, Carretera México Toluca S/N, La Marquesa, Ocoyoacac, Mexico. jorge.serment@inin.gob.mx
Abstract:
Casiopeinas is the generic name of a group of coordination complexes with a central copper atom bound to organic ligands, designed to be an alternative to cancer therapy. Indeed, some of these compounds can reduce implanted tumors in mice. Casiopeinas were expressly designed to interact with the genetic material, so the aim of the present work is to determine if these compounds have genotoxic activity. The results indicate that casiopeinas produce DNA fragmentation and base oxidation and suggest that their mode of action is related to reactive oxygen species (ROS) generation after copper reduction.
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