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Published on: December 2, 2022
Antiviral isoindolone derivatives from an endophytic fungus Emericella sp. associated with Aegiceras corniculatum
Guojian Zhang1, Shiwei Sun, Tianjiao Zhu
1Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, PR China.
Abstract:
Chemical investigation of the endophytic fungus Emericella sp. (HK-ZJ) isolated from the mangrove plant Aegiceras corniculatum led to isolation of six isoindolones derivatives termed as emerimidine A and B and emeriphenolicins A and D, and six previously reported compounds named aspernidine A and B, austin, austinol, dehydroaustin, and acetoxydehydroaustin, respectively. Their structures were elucidated on the basis of NMR spectroscopic evidence while the anti-influenza A viral (H₁N₁) activities of eight compounds were also evaluated using the cytopathic effect (CPE) inhibition assay.
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