Related Experiment Video
Updated: Jun 1, 2026
07:23
Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
Published on: August 6, 2021
Retinal vein occlusion: beyond the acute event
Justis P Ehlers1, Sharon Fekrat
1Vitreoretinal Service, Cole Eye Institute, Cleveland Clinic, Ohio, USA.
Survey of Ophthalmology
|May 24, 2011
Summary
Retinal vein occlusion, a leading cause of vision loss, involves understanding its causes and treatments. Recent trials guide management strategies for branch and central retinal vein occlusions.
Area of Science:
- Ophthalmology
- Retinal Vascular Diseases
Background:
- Retinal vein occlusion (RVO) is a significant cause of irreversible vision impairment.
- Both branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO) are common forms of RVO.
Purpose of the Study:
- To provide a comprehensive overview of the clinical aspects of RVO.
- To discuss the pathogenesis, natural history, and current management strategies for BRVO and CRVO.
Main Methods:
- Review of clinical features, pathogenesis, and natural history of RVO.
- Analysis of recent multicenter randomized clinical trials impacting RVO management.
- Evaluation of treatment options including surgical intervention, laser therapy, and pharmacotherapy.
Main Results:
- Recent clinical trials have significantly altered the management approach to RVO.
- Treatment strategies can target the underlying causes or the consequences of RVO.
Conclusions:
- Effective management of RVO requires a thorough understanding of its diverse clinical presentations and underlying mechanisms.
- Current therapeutic options offer various approaches to mitigate vision loss associated with RVO.
Related Concept Videos
01:27Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
01:30Venous Thrombosis I: Introduction
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
01:25Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
01:28Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...