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Failure of neuraxial anaesthesia in a patient with Velocardiofacial syndrome

V Cohen1, E Powell, C Lake

  • 1Department of Anaesthesia, Flinders Medical Centre, Bedford Park, South Australia, Australia. vcohen@doctors.org.uk

International Journal of Obstetric Anesthesia
|May 24, 2011
PubMed

Velocardiofacial or 22q11 deletion syndrome is a genetic condition caused by deletion 22q11, the deletion of a small segment of the long arm of chromosome 22. To our knowledge this is the first case report of a woman with Velocardiofacial syndrome presenting in late pregnancy for caesarean delivery. She had undergone a Tetralogy of Fallot repair as an infant and had residual pulmonary regurgitation. In addition examination revealed micrognathia and scoliosis. Neuraxial anaesthesia was unsuccessful and subsequent conversion to general anaesthesia was necessary despite concerns regarding her facial abnormalities, pulmonary regurgitation and mild intellectual impairment.

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