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Updated: Jun 1, 2026

Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
[Expression of Oct-4 transcription factor in squamous cell skin carcinoma and seborrheic keratosis]
Yu-yang Li1, Yong-jiang Dai, Bin Deng
1Department of Dermatology, Hainan Province Nongken Sanya Hospital, Sanya, China. syliyuyang@sohu.com
Objective:
To detect the expression of stem cell transcription factor Oct-4 in squamous cell carcinoma (SCC) and seborrheic keratosis (SK) and its association with cancer stem cells.
Methods:
Immunohistochemistry was used to detect Oct-4 expression in 35 SCC cases, 21 SK cases and 15 normal control skin tissues.
Results:
Oct-4 expression was negative in normal skin and showed a significant difference between SCC and SK tissues (P<0.05).
Conclusion:
The Oct-4-positive cells in SCC and SK are probably tumor stem cells. Oct-4 expression may provide an important evidence for isolation and identification of human SCC and SK stem cells.
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