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Oxidative stress in children with severe malaria
Nidhi Narsaria1, C Mohanty, B K Das
1Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India.
Journal of Tropical Pediatrics
|May 24, 2011
Summary
Severe malaria in children causes significant oxidative stress, indicated by increased harmful oxidant markers. Antioxidant defenses are depleted, suggesting a role for reactive oxygen species in the disease's development.
Area of Science:
- Biochemistry
- Pathology
- Pediatrics
Background:
- Severe malaria is a significant global health concern, particularly in children.
- Oxidative stress is implicated in the pathogenesis of various diseases, including malaria.
Purpose of the Study:
- To investigate the oxidant and antioxidant status in children with severe malaria.
- To explore the role of reactive oxygen species in the pathogenesis of severe malaria.
Main Methods:
- Studied 50 cases of severe malaria and compared them with controls.
- Measured plasma levels of malondialdehyde, protein carbonyl, nitrite, ascorbic acid, copper, ceruloplasmin, glutathione, superoxide dismutase, and zinc.
Main Results:
- Severe anemia was the most common presentation.
- Significantly elevated levels of malondialdehyde, protein carbonyl, nitrite, ascorbic acid, and copper were observed in severe malaria cases.
- Significantly decreased levels of ceruloplasmin, glutathione, and superoxide dismutase were found in children with severe malaria.
Conclusions:
- Elevated oxidant markers indicate increased oxidative stress in severe malaria.
- Depleted antioxidant levels suggest their utilization in combating oxidative damage.
- These findings highlight the potential role of reactive oxygen species in the pathogenesis of severe malaria.
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