Type 2 diabetes and the risk of renal cell cancer in women
Related Experiment Video
Updated: Jun 1, 2026

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice
Published on: January 12, 2024
Hee-Kyung Joh1, Walter C Willett, Eunyoung Cho
1Department of Nutrition, Harvard School of Public Health, and Brigham and Women’s Hospital, Boston, Massachusetts, USA.
Objective:
Type 2 diabetes is associated with increased risks of several types of cancer; however, its relationship to renal cell cancer remains unclear.
Research Design And Methods:
A total of 118,177 women aged 30 to 55 years at baseline (1976) were followed up through 2008 in the Nurses' Health Study. Self-reports of physician-diagnosed diabetes were collected at baseline and updated biennially. Hazard ratios (HRs) were calculated using Cox proportional hazards models with adjustment for age, BMI, hypertension, smoking, and parity.
Results:
During 32 years of follow-up (3,531,170 person-years), 16,819 cases of type 2 diabetes and 330 cases of pathology-confirmed incident renal cell cancer were documented. After multivariate adjustment, type 2 diabetes was significantly associated with an increased risk of renal cell cancer (HR 1.60 [95% CI 1.19-2.17]). These associations were consistent across different strata of BMI, smoking, and hypertension (Pinteraction≥0.32). The risk of renal cell cancer increased with an increasing number of comorbidities, including obesity, hypertension, and type 2 diabetes (Ptrend<0.001). When compared with women without any comorbidity, women who had all three conditions had a HR of 4.13 (2.76-6.18) for renal cell cancer.
Conclusions:
Type 2 diabetes is independently associated with an increased risk of renal cell cancer in women. In addition, comorbidity of obesity, hypertension, and type 2 diabetes substantially elevates the risk of renal cell cancer.
More Related Videos
10:31Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
09:52Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing (ChIP-seq)
Published on: April 19, 2013
Related Concept Videos
Type II Diabetes I: Introduction
Diabetes Mellitus: Type 2 and Gestational
Type II Diabetes II: Pathophysiology
Carbohydrate Metabolism
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in the...
Psychoneuroimmunology: Diabetes and Cancer
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis