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Melkersson-Rosenthal syndrome.

M R Orlando1, J S Atkins

  • 1Department of Otolaryngology-Head and Neck Surgery, Wilford Hall US Air Force Medical Center, Lackland Air Force Base, Tex.

Archives of Otolaryngology--Head & Neck Surgery
|June 1, 1990
PubMed
Summary

Melkersson-Rosenthal syndrome, a rare disorder, typically presents with facial swelling, tongue fissures, and facial palsy. This study highlights elevated angiotensin converting enzyme in two Thai patients with this condition.

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Area of Science:

  • Neurology
  • Immunology
  • Genetics

Background:

  • Melkersson-Rosenthal syndrome (MRS) is a rare neurological disorder.
  • MRS is characterized by facial edema, fissured tongue, and recurrent facial nerve palsy.

Observation:

  • Two cases of MRS in Thai patients were analyzed.
  • Elevated serum angiotensin converting enzyme (ACE) levels were observed in both patients.

Findings:

  • The study identified a correlation between MRS and elevated serum ACE levels.
  • This association was noted in patients of Thai descent.

Implications:

  • Findings suggest a potential role for ACE in the pathophysiology of MRS.
  • Further research may elucidate the diagnostic and therapeutic implications of ACE levels in MRS.
  • This study contributes to understanding rare disease variations across ethnicities.

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