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Diagnosis of heart failure with preserved ejection fraction: which parameters and diagnostic strategies are more

Xin-Xin Shuai1, Yu-Yuan Chen, Yong-Xin Lu

  • 1Department of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.

European Journal of Heart Failure
|May 24, 2011
PubMed

Insights

Diagnosing heart failure with preserved ejection fraction (HFpEF) is challenging. Key echocardiographic parameters like lateral E/e

Area of Science:

  • Cardiology
  • Medical Diagnostics
  • Echocardiography

Background:

  • Heart failure with preserved ejection fraction (HFpEF) lacks unified diagnostic criteria.
  • Accurate diagnosis is crucial for effective patient management and treatment strategies.

Purpose of the Study:

  • To evaluate current diagnostic criteria for HFpEF.
  • To identify the most valuable echocardiographic parameters and diagnostic strategies for HFpEF.

Main Methods:

  • Assessed echocardiographic data and N-terminal pro-brain natriuretic peptide levels in derivation (n=236) and validation (n=98) cohorts.
  • Included normal controls, patients with hypertensive heart disease without heart failure, and patients with HFpEF.
  • Evaluated single parameters and a brief diagnostic strategy.

Main Results:

  • Lateral E/e' ratio (≥12), left atrial volume index (LAVI ≥34 mL/m(2)), and Ard-Ad difference (>30 ms) showed the highest diagnostic value as single parameters.
  • A brief strategy using these parameters achieved 77% sensitivity and 81% specificity in the validation cohort.

Conclusions:

  • Echocardiographic parameters lateral E/e', LAVI, and Ard-Ad are highly valuable for diagnosing HFpEF.
  • A simple diagnostic strategy incorporating these parameters offers significant clinical utility for identifying diastolic dysfunction in HFpEF.
Abstract

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