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Published on: August 21, 2017
Expression and function of aquaporins in peripheral nervous system
Tong-hui Ma1, Hong-wen Gao, Xue-dong Fang
1Central Research Laboratory, Jilin University Bethune Second Hospital, Changchun 130041, China.
Acta Pharmacologica Sinica
|May 24, 2011
Summary
Aquaporin (AQP) water channels are crucial in the peripheral nervous system, particularly AQP1 in pain perception. This review highlights AQP roles in nerve function and potential therapeutic targets for neuropathies.
Area of Science:
- Neuroscience
- Molecular Biology
- Physiology
Background:
- The role of aquaporins (AQPs) in the peripheral nervous system (PNS) has been historically understudied.
- Recent advancements since 2004 have elucidated AQP expression, regulation, and function within the PNS.
Purpose of the Study:
- To review the progress in understanding AQPs in the peripheral nervous system.
- To discuss the involvement of AQPs in peripheral neuropathies and their potential as therapeutic targets.
Main Methods:
- Immunolocalization studies to identify AQP distribution.
- Functional characterization using transgenic knockout mouse models.
- Literature review of recent research on AQPs in the PNS.
Main Results:
- Selective localization of AQP1, AQP2, and AQP4 identified in various peripheral neurons and glial cells.
- Transgenic models demonstrated a significant role for AQP1 in pain perception.
- Evidence suggests AQPs are involved in the function of sensory neurons and nerve endings.
Conclusions:
- Aquaporins play a significant role in the peripheral nervous system, impacting neuronal function and pain signaling.
- Dysregulation of AQPs may contribute to peripheral neuropathies.
- Targeting AQPs presents a promising avenue for novel therapeutic strategies for neurological disorders.
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