Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Obstructive jaundice and wound healing.

L Grande1, J C Garcia-Valdecasas, J Fuster

  • 1Department of Surgery, Hospital Clinic i Provincial, University of Barcelona, Spain.

The British Journal of Surgery
|April 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Postoperative day one systemic inflammatory response syndrome is a powerful early biomarker of clinically relevant pancreatic fistula.

HPB : the official journal of the International Hepato Pancreato Biliary Association·2022
Same author

Factors Associated with Prolonged Recipient Hepatectomy Time During Liver Transplantation: A Single-Centre Experience.

World journal of surgery·2020
Same author

Role of Adult Living Donor Liver Transplantation in the Treatment of Hepatocellular Carcinoma Within and Beyond Milan Criteria: A Comparative Study.

Transplantation proceedings·2018
Same author

Probing lepton flavour violation via neutrinoless [Formula: see text] decays with the ATLAS detector.

The European physical journal. C, Particles and fields·2017
Same author

A new method to distinguish hadronically decaying boosted <i>Z</i> bosons from <i>W</i> bosons using the ATLAS detector.

The European physical journal. C, Particles and fields·2017
Same author

Search for supersymmetry at [Formula: see text] TeV in final states with jets and two same-sign leptons or three leptons with the ATLAS detector.

The European physical journal. C, Particles and fields·2017
Same journal

Trimester-Specific Safety of Laparoscopic versus Open Abdominal Surgery During Pregnancy: A Systematic Review and Meta-analysis.

The British journal of surgery·2026
Same journal

The Gut Microbiome in Surgical Oncology: Mechanisms, Perioperative Outcomes, and Therapeutic Opportunities.

The British journal of surgery·2026
Same journal

Patient-led, home-based follow-up for colorectal cancer: the DISTANCE multicentre stepped-wedge cluster-randomised trial.

The British journal of surgery·2026
Same journal

Correction to: Reduced secretory efficiency in parathyroid carcinoma: diagnostic value of the PTH-to-tumour-volume ratio.

The British journal of surgery·2026
Same journal

Global disparities in hepatocellular carcinoma outcomes: multicentre study.

The British journal of surgery·2026
Same journal

Surgical Outcomes from Nationwide Implementation of the International Best-Practice for Locally Advanced Pancreatic Cancer (PREOPANC-4) study.

The British journal of surgery·2026
See all related articles

Jaundiced patients exhibit impaired wound healing due to lower collagen synthesis, indicated by reduced skin prolylhydroxylase activity. This significantly increases the risk of abdominal wound dehiscence, a complication linked to low enzyme levels.

Area of Science:

  • Biochemistry
  • Surgical Research
  • Gastroenterology

Background:

  • Jaundice, a condition characterized by yellowing of the skin and eyes, can impact physiological processes.
  • Collagen synthesis is crucial for effective wound healing.
  • Skin prolylhydroxylase activity serves as a biomarker for collagen production.

Purpose of the Study:

  • To investigate the relationship between jaundice and wound healing.
  • To assess collagen synthesis in jaundiced patients using skin prolylhydroxylase activity.
  • To determine the correlation between jaundice, collagen synthesis, and the incidence of abdominal wound dehiscence.

Main Methods:

  • A comparative study involving 95 jaundiced patients and 123 anicteric controls.
  • Measurement of skin prolylhydroxylase activity as an indicator of collagen synthesis.

Related Experiment Videos

  • Analysis of abdominal wound dehiscence rates in both groups.

    • Main Results:

    • Jaundiced patients showed significantly lower preoperative skin prolylhydroxylase activity compared to controls (40.1 vs. 369.2 c.p.m./mg protein).
    • Activity levels differed between benign (55.0 c.p.m./mg protein) and malignant biliary obstruction (25.2 c.p.m./mg protein).
    • Abdominal wound dehiscence occurred more frequently in jaundiced patients (6/95) than in anicteric patients (2/123), correlating with low prolylhydroxylase activity.

    Conclusions:

    • Jaundice is associated with reduced collagen synthesis, evidenced by decreased skin prolylhydroxylase activity.
    • Low prolylhydroxylase activity in jaundiced patients is linked to an increased risk of abdominal wound dehiscence.
    • Biliary obstruction type influences prolylhydroxylase activity, with malignant obstruction showing poorer recovery of enzyme levels.