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Updated: Jun 1, 2026

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
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Drug nanoparticle formulation using ascorbic Acid derivatives.

Kunikazu Moribe1, Waree Limwikrant, Kenjirou Higashi

  • 1Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8675, Japan.

Journal of Drug Delivery
|May 24, 2011
PubMed
Summary

Ascorbic acid derivatives are explored for drug nanoparticle formulation. Ascorbyl glycoside aids drug solubilization and nanoparticle formation, while fatty acid derivatives form drug carriers and anticancer nanoparticles.

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Area of Science:

  • Pharmaceutical Science
  • Materials Science

Background:

  • Ascorbic acid derivatives are emerging in drug formulation.
  • Hydrophilic derivatives like ascorbyl glycoside act as antioxidants and excipients.
  • Hydrophobic derivatives are utilized as drug components or carriers.

Purpose of the Study:

  • To explore the use of ascorbic acid derivatives in drug nanoparticle formulation.
  • To investigate the role of ascorbyl glycoside in drug solubilization and nanoparticle formation.
  • To review the application of hydrophobic ascorbic acid derivatives in various nanoparticle systems.

Main Methods:

  • Formulation of drug nanoparticles using ascorbic acid derivatives.
  • Characterization of nanoparticle systems like micelles, microemulsions, and liposomes.

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  • Evaluation of therapeutic applications, including antioxidant and anticancer uses.

    • Main Results:

    • Ascorbyl glycoside facilitates drug solubilization and nanoparticle formation.
    • Hydrophobic ascorbic acid derivatives are effective in formulating nanoparticles for drug delivery.
    • Ascorbyl palmitate is a key component in developing aspasomes (ASC-P vesicles) for hydrophilic drug encapsulation.

    Conclusions:

    • Ascorbic acid derivatives offer versatile platforms for drug nanoparticle formulation.
    • These derivatives can be tailored for specific drug delivery applications, enhancing solubility and therapeutic efficacy.
    • The development of novel nanoparticle systems like aspasomes holds promise for advanced drug delivery.