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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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Related Experiment Video

Updated: Jun 1, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

MicroRNA in Melanoma.

Paul M Howell, Xiaobo Li, Adam I Riker

    Ochsner Journal
    |May 24, 2011
    PubMed
    Summary

    MicroRNAs (miRNAs) are key regulators in melanoma development. Understanding these small RNAs and their targets is crucial for developing new melanoma therapies and improving patient outcomes.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Genetics

    Background:

    • Melanoma is an aggressive skin cancer with increasing incidence and high mortality in advanced stages.
    • Limited treatment options exist for metastatic melanoma, emphasizing the need for novel therapeutic strategies.
    • Genetic and epigenetic factors, including microRNAs (miRNAs), play critical roles in melanoma progression.

    Purpose of the Study:

    • To review current data on melanoma-associated miRNAs.
    • To highlight deregulated miRNAs targeting key genes and pathways in melanoma.
    • To underscore the importance of miRNAs in melanoma progression and metastasis.

    Main Methods:

    • Literature review of studies on microRNAs in melanoma.
    • Analysis of miRNA deregulation in melanocyte transformation and melanoma metastasis.
    Keywords:
    EpigeneticsmelanomametastasismicroRNA

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    MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
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  • Identification of target genes and signaling pathways affected by melanoma-associated miRNAs.

    • Main Results:

    • Numerous miRNAs are deregulated in melanoma, impacting critical cellular processes.
    • Specific miRNAs target genes and pathways involved in melanoma cell proliferation, survival, and metastasis.
    • miRNA dysregulation is implicated in the transition from primary to metastatic melanoma.

    Conclusions:

    • MicroRNAs are significant regulators of melanoma development and progression.
    • Understanding miRNA roles offers potential for novel diagnostic and therapeutic approaches.
    • Targeting miRNAs may lead to effective treatments for advanced melanoma and metastasis.