New Onset LSD Flashback Syndrome Triggered by the Initiation of SSRIs

During the 1960s, lysergic acid diethylamide (LSD) emerged as a widely popular drug, used by a substantial portion of the adolescent and young adult population. Since Major Depressive Disorder is a common disorder, clinicians will increasingly encounter patients who used LSD in the far distant past and now require treatment with antidepressant agents. We describe such a case in the following report of a patient who experienced a troubling array of unusual side effects, which we postulate to be a new onset LSD flashback syndrome triggered by selective serotonin reuptake inhibitors (SSRIs).